Urological Tumors of Children

By Philip E. Gleason, MD


Pediatric Tumors are obviously some of the most devastating Pediatric Urologic diagnoses. Fortunately, tremendous progress is being made treating Pediatric Urologic tumors with both survival and morbidity. These section topics will provide introductory information regarding these diagnoses.


Pediatric Urologic tumors include Wilm's tumors, Congenital Mesonephric Blastoma (CMN), Neuroblastomas, Rhabdomyosarcomas and Pre-pubertal Testis Tumors.


Hallmarks of pediatric oncology in general, and including pediatric urologic tumors, are cooperative trials across the United States . Since pediatric urologic tumors are rare, it is difficult to gain a large experience for study and treatment in any one hospital, medical center, city or state. However, by enrolling and combining children from across the United States in study treatment and follow-up protocols, very precise experimental and treatment protocols can be designed and followed to assess the best treatments with the lowest side effects, and then revised to progress to the next best treatments and to further reduce side effects. These are now handled through the Children's Oncology Group of the National Cancer Institute. Thus, although it is sometimes disconcerting for families to feel that their child is not receiving individualized treatment, they are in fact receiving treatment based upon expert opinion and second opinions from across the United States .


A second hallmark is the development of multi-modal treatments which combine the best advantages of several different treatments for tumors including surgery to remove the tumors, or chemotherapy to poison the tumors, or radiation therapy to kill the tumors. This combination approach also allows treatments to be combined to try to minimize and negate side effects as well. As treatments and survival and side effects from treatment of pediatric tumors improves, long term side effects and complications, known as late effects, are becoming more important.


We will now discuss more specific Pediatric Urologic Tumors.



© 2005-2010, Dr. Philip E. Gleason, MD